Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5851155 | Food and Chemical Toxicology | 2013 | 8 Pages |
Abstract
The rats were submitted, or not, to FA inhalation (1%, 90Â min/day, 3Â days) and were OVA-sensitised and challenged 14Â days later. Our data showed that previous FA exposure in allergic rats reduced bronchial responsiveness, respiratory resistance (Rrs) and elastance (Ers) to methacholine. FA exposure in allergic rats also increased the iNOS gene expression and reduced COX-1. L-NAME treatment exacerbated the bronchial hyporesponsiveness and did not modify the Ers and Rrs, while Indomethacin partially reversed all of the parameters studied. The L-NAME and Indomethacin treatments reduced leukotriene B4 levels while they increased thromboxane B2 and prostaglandin E2. In conclusion, FA exposure prior to OVA sensitisation reduces the respiratory mechanics and the interaction of NO and PGE2 may be representing a compensatory mechanism in order to protect the lung from bronchoconstriction effects.
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Authors
Adriana Lino-dos-Santos-Franco, João Antonio Gimenes-Júnior, Ana Paula Ligeiro-de-Oliveira, Ana Cristina Breithaupt-Faloppa, Beatriz Golegã Acceturi, Luana Beatriz Vitoretti, Isabel Daufenback Machado, Ricardo Martins Oliveira-Filho,