| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5851256 | Food and Chemical Toxicology | 2013 | 10 Pages |
Abstract
⺠Rats were orally exposed up to 28 days to a mixture of phenanthrene, pyrene and benzo(a)pyrene. ⺠EROD activity induction kinetics were established in brain, liver and peripheral blood lymphocytes (PBLs). ⺠EROD activity in PBL is linearly correlated to EROD activity in liver and brain. ⺠It appears as a non-lethal and convenient bioindicator of exposure to PAH in animals with sufficient blood volume. ⺠We suggest its use for evaluating exposure of (farm) animals to CYP 1A1/1B1 inducing compounds, in a non-specific way.
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Authors
Abir Chahin, Julie Peiffer, Jean-Charles Olry, Guillemette Crepeaux, Henri Schroeder, Guido Rychen, Yann Guiavarc'h,