| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5851286 | Food and Chemical Toxicology | 2013 | 16 Pages |
Abstract
⺠Low-protein intake worsens cisplatin, 5-fluorouracil and mitomycin C gastrotoxicity. ⺠Protein malnutrition enhances metabolic activation of cisplatin in rat stomach. ⺠Malnutrition enhances cysteine conjugate β-lyase-mediated metabolism of cisplatin. ⺠Protein malnutrition reduces the elimination of 5-fluorouracil in rat stomach. ⺠Protein malnutrition enhances 2-electron reduction of mitomycin C in rat stomach.
Keywords
APNGSHIL-4GSTCOX-2iNOSCyPPGE2MMCGCsMitomycin CDPDMDAGGTDCVCQR1quinone reductase 1Xanthine oxidaseROSmitochondrial aspartate aminotransferaseAminopeptidase NOrotate phosphoribosyltransferaseinterleukin-4tumor necrosis factor-alphaOPRTdihydropyrimidine dehydrogenaseinducible nitric oxide synthaseProtein malnutritionCytochrome P450cisplatinCyclooxygenase-2antioxidant response elementTNF-α5-fluorouracilmalondialdehydeGastric toxicityNitric oxideAREProstaglandin E2Gamma-glutamyltransferaseGamma-glutamylcysteine synthetaseGlutathioneglutathione S-transferaseReactive oxygen species
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Authors
Tarek K. Motawi, Hanan M. Abd-Elgawad, Nancy N. Shahin,