| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5851300 | Food and Chemical Toxicology | 2013 | 8 Pages |
Abstract
⺠Consumption of 1000 mg of FraxiPure⢠for 90 days was well tolerated by 50 healthy volunteers in a placebo controlled RCT. ⺠No significant changes in biochemical or hematological parameters were observed between the FraxiPure⢠and control groups. ⺠An acute toxicity study revealed an LD50 of >2500 mg/kg for FraxiPure⢠in Sprague-Dawley rats. ⺠FraxiPure⢠protected human lymphocytes from the effects of irradiation as determined by the micronucleus assay. ⺠An IC50 value of 1.447 mg/mL was calculated in Vero cell lines using the MTT assay.
Keywords
TLDSecoiridoidMCVGGTPMCHCGCPMCHPPARαCRFGMPALTFBSRBCWBCRed blood cellsAUCASTAspartate aminotransferasealanine transaminaseClinical safetyGood Manufacturing PracticeThermoluminescent dosimetersmicronucleifetal bovine serumToxicityadverse eventgood clinical practicecase report formmean corpuscular hemoglobinarea under the curveMean corpuscular hemoglobin concentrationgamma-glutamyl transpeptidasewhite blood cellsperoxisome proliferator-activated receptor-alpha
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Authors
John Flanagan, Marjolaine Meyer, MarÃa Angeles Pasamar, Alvin Ibarra, Marc Roller, Nuria Alvarez i Genoher, Sandra Leiva, Francisco Gomez-GarcÃa, Miguel Alcaraz, Alberto MartÃnez-Carrasco, Vicente Vicente,