| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5851575 | Food and Chemical Toxicology | 2013 | 15 Pages |
Abstract
⺠MCPT exerts antitumor effect against human cancer cells. However, the mechanism is poorly understood. ⺠MCPT induced cytotoxicity in seven human cancer cells. ⺠MCPT induced apoptosis, arrested cell cycle, increased ROS generation and the activities of caspases in A2780 and Hela cells. ⺠MCPT induced up-regulation expression of genes and proteins in both cells, with the TNFα and Fas/FasL pathway more prominent. ⺠MCPT may be a potent therapeutic agent against human cancers.
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Authors
Haiyan Wang, Mingzhang Ao, Jiayi Wu, Longjiang Yu,