| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5851828 | Food and Chemical Toxicology | 2013 | 6 Pages |
â¢BHT attenuates toxic effects of Fe-NTA.â¢BHT can serve as potent chemopreventive agent.â¢BHT protects against Fe-NTA-mediated renal damage in rats.â¢BHT suppresses oxidative stress and nephrotoxicoty caused by Fe-NTA.
This study was designed to investigate the effect of butylated hydroxy toluene (BHT), a phenolic antioxidant used in foods, cosmetics and pharmaceutical products, on Fe-NTA-induced nephrotoxicity in rats. Fe-NTA (alone) treatment enhances ornithine decarboxylase activity to 5.3-fold, and [3H] thymidine incorporation in DNA to 3.5-fold compared with the corresponding saline treated control. The enhanced ornithine decarboxylase activity and DNA synthesis showed a reduction to 2.12-2.15-fold respectively at a higher dose of 2Â mg BHT/day/animal, compared with the Fe-NTA treated group. Fe-NTA treatment also enhanced the renal microsomal lipid peroxidation to 2.0-fold and decreased the activities of glutathione and antioxidant enzymes to a range of 2.2-2.5-fold in kidney. These changes were reversed significantly in animals receiving a pretreatment of BHT. Present data suggests that BHT can prevent the toxic effects of Fe-NTA and can serve as a potent chemopreventive agent to suppress oxidant-induced tissue injury and nephrotoxicity in rats.
