| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5851849 | Food and Chemical Toxicology | 2013 | 8 Pages |
Abstract
⺠Maytenus procumbens (L.M.P) showed the highest cytotoxicity on HeLa cells. ⺠A new triterpene: '30-hydroxy-11α-methoxy-18β-olean-12-en-3-one' (HMO) was isolated. ⺠HMO caused DNA damage and appeared genotoxic to HeLa cells. ⺠HMO induced apoptosis in HeLa cells through ROS generation.
Keywords
RSC13CNMRDCFH-DATBARSDMEMFBS1HNMRDPPHTLCAnnexin V-FITCHMOFRAPnuclear magnetic resonance2,7-dichlorofluorescin diacetate3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromideDMSOMTTROSAsiatic acidNMROxidative stressApoptosisdimethyl sulphoxidecarbon nuclear magnetic resonancefetal bovine serumCytotoxicityRadical scavenging capacityferric-reducing antioxidant powerDulbecco’s modified eagle’s mediumthiobarbituric acid reactive substancePropidium iodideproton nuclear magnetic resonancethin layer chromatographyReactive oxygen species
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Authors
S. Momtaz, A.A. Hussein, S.N. Ostad, M. Abdollahi, N. Lall,