Interactions of sulforaphane and dimethyl sulfoxide with methyl methanesulfonate, urethane, 4-nitroquinoline-1-oxide and hydrogen peroxide in the Drosophila melanogaster wing spot test

► We confirm that, in the ST cross, Sulforaphane (SF) is genotoxic at 0.14 mM. ► We found in the HB cross that SF (0.28 mM) was genotoxic. ► We report a reduction of damage caused by MMS and URE, by the scavenger action of DMSO, which was used as a solvent for SF. ► Co-treatments SF and 4-NQO or H2O2 indicate a modulation in the expression of the CYP450s and a DMSO's antioxidant effect.