Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5852128 | Food and Chemical Toxicology | 2013 | 8 Pages |
Abstract
The study was carried out to evaluate the subchronic toxicity of meat derived from human lactoferrin gene-modified cattle in male and female Wistar rats. Rats were fed 5% or 10% transgenic meat diet, 5% or 10% conventional meat diet, or AIN93G diet for 90Â days. During the study, body weight and food consumption were weighed weekly and clinical observations were conducted daily. At the end of the study, urinary examination, hematology and blood biochemistry examination, macroscopic and microscopic examinations were performed. There were no biologically significant differences in these factors between the rat groups fed transgenic meat diet and conventional meat diet. Therefore, the present 90-day rodent feeding study suggests that meat derived from the transgenic cattle is equivalent to meat from conventional cattle in use as dietary supplements.
Keywords
FDAEFSAAPTTSCNTWBCRBCALTA/GASTAspartate aminotransferaseAlanine aminotransferaseALPAlkaline phosphataseEuropean Food Safety AuthoritySomatic cell nuclear transferred blood cell countBUNactivated partial thromboplastin timeprothrombin timeFood and Drug AdministrationWhite blood cell countlactate dehydrogenaseLDHHuman lactoferrinRecombinant human lactoferrin90-Day feeding studyRatalbumin/globulin ratioblood urea nitrogenCreatine kinasetotal proteinCHECholinesteraseMeat
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Authors
Shan Liu, Chen-Xi Li, Xiao-Lian Feng, Hui-Ling Wang, Hai-Bo Liu, Yuan Zhi, Gui-Ying Geng, Jie Zhao, Hai-Bin Xu,