Lack of cytotoxic and genotoxic effects of Minthostachys verticillata essential oil: Studies in vitro and in vivo

Article ID	Journal	Published Year	Pages	File Type
5852188	Food and Chemical Toxicology	2012	6 Pages	PDF

Abstract

âº Toxicity and chemical composition of Minthostachys verticillata essential oil were studied. âº The main compounds were pulegone, menthone and limonene. âº The essential oil not induced cytotoxic effect both on Vero cell and human PBMCs. âº The oil not induced apoptosis on human PBMCs nor genotoxicity on erythrocytes of mice. âº The results suggest this species appears to be a safe therapeutic agent.

Keywords

PBMCs FCS NCE PCE MNPCE micronucleated polychromatic erythrocytes GC–FID NRU polychromatic erythrocytes normochromatic erythrocytes neutral red uptake Apoptosis foetal calf serum peripheral blood mononuclear cells Cytotoxicity Genotoxicity Essential oil Micronucleus Hydrodistillation Gas chromatography

Related Topics

Life Sciences Agricultural and Biological Sciences Food Science

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Lack of cytotoxic and genotoxic effects of Minthostachys verticillata essential oil: Studies in vitro and in vivo

Authors

Franco MatÃas Escobar, Laura Noelia Cariddi, MarÃa Carola Sabini, Elina Reinoso, Sonia Beatriz Sutil, Cristina Vanesa Torres, Silvia Matilde Zanon, Liliana Inés Sabini,