| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5852214 | Food and Chemical Toxicology | 2012 | 8 Pages |
Abstract
⺠Rifampin possess the species-specific protection against the liver injury induced by acetaminophen in mice. ⺠Rifampin enhanced the biotransformation of acetaminophen to p-aminophenol. ⺠Rifampin reduced glutathione depletion in vivo and in vitro. ⺠Microsomal drug-metabolizing enzyme and glutathione reductase activity was increased by treatment with rifampin. ⺠Microsomal Ca2+-ATPase activity was not directly related to acetaminophen toxic metabolites in vitro.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Food Science
Authors
Min He, Shijun Zhang, Yang Jiao, Xing Lin, Jianchun Huang, Chunxia Chen, Zhaoni Chen, Renbin Huang,