A flavonoid component from Docynia delavayi (Franch.) Schneid represses transplanted H22 hepatoma growth and exhibits low toxic effect on tumor-bearing mice

Article ID	Journal	Published Year	Pages	File Type
5852219	Food and Chemical Toxicology	2012	8 Pages	PDF

Abstract

âº Chrysin contributed to the anti-tumor activity of the herb “Duoyi”. âº Chrysin repressed in vivo growth of transplanted H22 tumor cells. âº Chrysin exhibited low toxicology effects to tumor-bearing mice. âº Chrysin induced transplant tumor cell apoptosis in vivo. âº The anti-angiogenesis effect of chrysin was directly evaluated.

Keywords

Huh7 CRE H22 EC1 A549 CDDP WBC PLT RBC ALT Red blood cells MTT AST Angiogenesis Toxic effect Uric acid BUN Hepatic cancer cisplatin Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)Anti-tumor activity blood urea nitrogen Hemoglobins Hgb Vero Platelets creatinine Chrysin white blood cells