| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5852225 | Food and Chemical Toxicology | 2012 | 8 Pages |
Abstract
⺠PCP isolated from Paecilomyces cicadae increases NO production and cytokine gene expression in macrophages. ⺠PCP activates macrophages through TLR4 membrane receptor. ⺠PCP activates MAPKs and NF-κB signaling downstream from TLR4. ⺠NF-κB and p38 play a crucial role in PCP-induced NO production by macrophages.
Keywords
IκBPMBCR3SEAPPRRsTLR4TLRERKPCPJnkNF-κBLPSc-Jun N-terminal kinaseMAPKsmall interfering RNAssiRNAToll-like receptornuclear factor-κBlipopolysaccharideMacrophagebone marrow-derived macrophageNitric oxidemitogen-activated protein kinasepolymyxin BPolysaccharideextracellular signal-regulated kinaseComplement receptorpattern recognition receptors
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Authors
Hyung Sook Kim, Yeon Jin Kim, Hong Kyung Lee, Hwa Sun Ryu, Ji Sung Kim, Mi Jung Yoon, Jong Soon Kang, Jin Tae Hong, Youngsoo Kim, Sang-Bae Han,