| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5852254 | Food and Chemical Toxicology | 2012 | 7 Pages |
Abstract
⺠Alantolactone caused apoptosis and arrest of cells in G2-M phase in HepG2 cells. ⺠Caspase-8 and Bid activation, and cytochrome c release were observed. ⺠These suggest the existence of a cross-talk between two apoptotic pathways. ⺠Alantolactone regulated the expression of p53 and NF- κB/p65. ⺠Our data suggest that alantolactone could be a useful agent against liver cancer.
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Authors
Jia-Chuan Lei, Jian-Qing Yu, Yan Yin, Yan-Wen Liu, Guo-Lin Zou,