Combined treatment with capsaicin and resveratrol enhances neuroprotection against glutamate-induced toxicity in mouse cerebral cortical neurons

► Capsaicin or resveratrol protects cerebral cortical neurons against glutamate toxicity. ► Capsaicin or resveratrol reduces oxidative stress and apoptosis induced by glutamate in neurons. ► Capsaicin or resveratrol down-regulates pro-inflammatory cytokine overexpressions induced by glutamate in neurons. ► Combined treatment with both phytochemicals further enhances the neuroprotection activities in glutamate-treated neurons. ► These strategies in a post-treatment paradigm could be a useful therapeutic application for the neurodegenerative disorders.