Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5852286 | Food and Chemical Toxicology | 2012 | 9 Pages |
Abstract
⺠Capsaicin or resveratrol protects cerebral cortical neurons against glutamate toxicity. ⺠Capsaicin or resveratrol reduces oxidative stress and apoptosis induced by glutamate in neurons. ⺠Capsaicin or resveratrol down-regulates pro-inflammatory cytokine overexpressions induced by glutamate in neurons. ⺠Combined treatment with both phytochemicals further enhances the neuroprotection activities in glutamate-treated neurons. ⺠These strategies in a post-treatment paradigm could be a useful therapeutic application for the neurodegenerative disorders.
Keywords
Sirt1H2DCF-DA2′,7′-dichlorodihydrofluorescin diacetateTRPV1DMEMManganese SODGPx1SOD2SOD1IL-1βMTTROSInterleukin-1βtumor necrosis factor-αCNScentral nervous systemTNF-αDulbecco’s modified eagle’s mediumcopper/zinc superoxide dismutaseSilent mating type information regulation 2 homolog 1Transient receptor potential vanilloid 1Reactive oxygen species
Related Topics
Life Sciences
Agricultural and Biological Sciences
Food Science
Authors
Jong-Geol Lee, Jung-Min Yon, Chunmei Lin, A. Young Jung, Ki Youn Jung, Sang-Yoon Nam,