| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5852338 | Food and Chemical Toxicology | 2012 | 6 Pages |
Abstract
⺠Sheets of mucosa and epithelial monolayers were used to examine functional effects of patulin. ⺠Patulin increased epithelial permeability and also inhibited ion transport. ⺠Exposure to patulin evoked structural damage in intact tissues. ⺠Patulin's actions results from cytotoxicity as evidenced by high content analysis.
Keywords
PMPKrebs–Henseleit bufferTEERCCHCaco-2MMPpotential differencehigh content analysisToxicologycell numberapparent permeability coefficientmucosatransepithelial electrical resistanceNuclear AreaPlasma membrane permeabilityPatulinPappMitochondrial membrane potentialCarbacholIntracellular calciumRat colon
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Authors
H.M. Mohan, D. Collins, S. Maher, E.G. Walsh, D.C. Winter, P.J. O'Brien, D.J. Brayden, A.W. Baird,