Toxicologic evaluations of DHA-rich algal oil in rats: Developmental toxicity study and 3-month dietary toxicity study with an in utero exposure phase

Article ID	Journal	Published Year	Pages	File Type
5852362	Food and Chemical Toxicology	2012	9 Pages	PDF

Abstract

âº A subchronic study in the rat did not produce significant toxicologic findings. âº A reproductive study in the rat did not result in evidence of reproductive toxicity. âº A developmental study in the rat did not produce significant developmental effects. âº Results support the safety of DHA-rich algal oil for its proposed use in food.

Keywords

mg/kg ALB ppm GRAS WBC HCT RBC ALT OECD ONC MCH ALKP MCHC RRV MPV MCV sorbitol dehydrogenase NOAEL FOB HDW treatment group PND CFR EPA SOP GGT CHOL SDH TRT US FDA AST Aspartate aminotransferase Alanine aminotransferase Albumin Alkaline phosphatase United States Food and Drug Administration Eicosapentaenoic acid docosahexaenoic acid Polyunsaturated fatty acids PUFA functional observation battery generally recognized as safe analysis of variance ANOVA trig Triglycerides total white blood cell count red blood cell count Mean corpuscular volume BUN DHA postnatal day standard operating procedure Time Organisation for Economic Co-operation and Development Sodium Developmental toxicity Reproductive toxicity Red cell distribution width Hemoglobin concentration time interval Motor activity parts per million mean platelet volume mean corpuscular hemoglobin Mean corpuscular hemoglobin concentration first generation Algal oil blood urea nitrogen hematocrit Hgb No observed adverse effect level Potassium Code of Federal Regulations glob total protein Chloride total cholesterol Calcium gamma glutamyltransferase Globulin Glucose Gluc