| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5852399 | Food and Chemical Toxicology | 2012 | 7 Pages |
Abstract
⺠Chitosan oligosaccharides (COS) inhibited CYP enzymes in rat liver. ⺠COS induced phase II detoxifying reactions in rat liver and kidneys. ⺠The modulation of COS on the activity of CYP isozymes is tissue-specific.
Keywords
UGTTBARSGSSGCOSNQO1GSTGSHCyPDPPHDMESDS1,1-diphenyl-2-picrylhydrazylROSUDP-glucuronosyltransferaseDrug-metabolizing enzymesMass spectrometricChitosan oligosaccharidesOxidative stresssodium dodecyl sulfatecytochrome P-450thiobarbituric acid reactive substancesRatsreduced glutathioneLiverhigh-performance liquid chromatographyHPLCKidneysglutathione S-transferaseoxidized glutathioneReactive oxygen species
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Authors
Hsien-Tsung Yao, Mei-Ning Luo, Lang-Bang Hung, Meng-Tsan Chiang, Jia-Hsuan Lin, Chong-Kuei Lii, Chun-Yin Huang,