p-Methoxyl-diphenyl diselenide protects against cisplatin-induced renal toxicity in mice

Article ID	Journal	Published Year	Pages	File Type
5852402	Food and Chemical Toxicology	2012	7 Pages	PDF

Abstract

âº (OMePhSe)2 protects against renotoxicity induced by cisplatin in mice. âº (OMePhSe)2 attenuated histopathological alterations induced by cisplatin exposure in mice. âº The increase in urea and creatinine levels resulting of cisplatin exposure in mice was protected by (OMePhSe)2. âº (OMePhSe)2 protected against the inhibition of renal CAT, GST, GPx and GR activities caused by cisplatin exposure in mice.

Keywords

δ-ALA-D GPX OPA GST GSH TCA GSSG CAT Dcf MDA TBARS CDNB SDS dichlorofluorescein DCHF-DA nuclear magnetic resonance 1-chloro-2,4-dinitrobenzene 2′,7′-dichlorofluorescein diacetate GC/MS o-Phthalaldehyde ROS Ascorbic acid Antioxidant trichloroacetic acid NMR sodium dodecyl sulfate Selenium sulfhydryl cisplatin malondialdehyde Mice Catalase reduced glutathione gas chromatography/mass spectrometry glutathione S-transferase oxidized glutathione glutathione reductase glutathione peroxidase thiobarbituric acid reactive species Reactive oxygen species