Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: Roles of apoptotic cell death and LS1034 tumor xenografts model

Article ID	Journal	Published Year	Pages	File Type
5852415	Food and Chemical Toxicology	2012	8 Pages	PDF

Abstract

âº Up-regulation of the levels of caspase cascade in emodin-treated LS1034 cells. âº Activation of apoptotic signaling in LS1034 cells after emodin exposure. âº Suppression of xenografts tumor growth in athymic nude mice by emodin.

Keywords

Endonuclease G ΔΨm Bcl-2 DCFH-DA DAPI 2′,7′-dichlorofluorescin diacetate 4,6-diamidino-2-phenylindole dihydrochloride DMSO Endo G AIF Emodin Bax Xenograft tumor Apoptosis Dimethyl sulfoxide apoptosis-inducing factor B-cell lymphoma 2 Mitochondrial membrane potential Bcl-2-associated X protein Propidium iodide

Related Topics

Life Sciences Agricultural and Biological Sciences Food Science

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Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: Roles of apoptotic cell death and LS1034 tumor xenografts model

Authors

Yi-Shih Ma, Shu-Wen Weng, Meng-Wei Lin, Chi-Cheng Lu, Jo-Hua Chiang, Jai-Sing Yang, Kuang-Chi Lai, Jing-Pin Lin, Nou-Ying Tang, Jaung-Geng Lin, Jing-Gung Chung,