| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5852506 | Food and Chemical Toxicology | 2017 | 7 Pages |
Abstract
⺠HepG2/C3A cells were used to assess the cellular effects of three oil dispersants. ⺠The Corexit dispersants were significantly more cytotoxic than ZI-400. ⺠The dispersants increased levels of ROS and altered several cellular processes. ⺠DOSS made notable contributions to the cellular effects of the Corexit dispersants. ⺠This model may be a complementary tool for predicting toxicity of complex mixtures.
Keywords
FCCPOil dispersantsdihydrodichlorofluorescein diacetateR123DCFDAdichlorofluoresceinethoxyresorufin-O-deethylaseDOSSERODDcfHEPESDMEMROShydroxyethyl piperazineethanesulfonic acidRhodamine 123HepatotoxicityDulbecco’s modified eagle’s mediumChemical mixturescarbonyl cyanide 4-(trifluoromethoxy)phenylhydrazoneReactive oxygen species
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Authors
Omari J. Bandele, Michael F. Santillo, Martine Ferguson, Paddy L. Wiesenfeld,