| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5852697 | Food and Chemical Toxicology | 2012 | 8 Pages |
Abstract
⺠Genotoxic effect of patulin after systemic administration was evaluated in mice. ⺠Dose-dependent increase in DNA strand breaks (brain, liver, kidneys) was detected. ⺠Decreased level of GSH and increased lipid peroxidation were also observed. ⺠Pre-treatment with N-acetyl-cysteine restored GSH levels and reduced DNA damage. ⺠Our results showed correlation between pro-oxidant and genotoxic effects of patulin.
Keywords
MDAHBSSMMSDTNBTBARSN-acGSSGGSHTCANADPHTMPTBAPBSN-acetyl-cysteineOxidative damagetrichloroacetic acidThiobarbituric acidComet assayGenotoxicitymalondialdehydeMethyl methanesulphonatePhosphate-buffered salineHank’s balanced salt solutionMycotoxinPatulinreduced glutathioneoxidized glutathioneglutathione reductasethiobarbituric acid-reactive species
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Authors
Flávia Terezinha de Melo, Iuri Marques de Oliveira, Samuel Greggio, Jaderson Costa Dacosta, Temenouga Nikolova Guecheva, Jenifer Saffi, João Antonio Pêgas Henriques, Renato Moreira Rosa,