| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5852704 | Food and Chemical Toxicology | 2012 | 10 Pages |
Abstract
⺠DHA-rich algal oil ONC-T18 did not show mutagenic or genotoxic potential. ⺠90-day dietary study of DHA-rich algal oil produced no significant toxicity. ⺠Oral LD50 in rats estimated to be greater than 5000 mg/kg of body weight. ⺠Results support the safety of DHA-rich algal oil for its proposed use in food.
Keywords
ALTSDHALBMCVWBCrecHCTRBCMCHCGRASmg/kg2AA2-aminoanthraceneNCEALKPMCHONCOECDsorbitol dehydrogenaseTOXCHOL2NFFOBNOAELLD50CFRMitomycin CPCEMMC2-nitrofluoreneDMSOUS FDAASTAspartate aminotransferaseAlanine aminotransferaseAlbuminAlkaline phosphataseUnited States Food and Drug Administrationpolychromatic erythrocytesnormochromatic erythrocytesdocosahexaenoic acidPolyunsaturated fatty acidsPUFAfunctional observation batterygenerally recognized as safeanalysis of varianceANOVAtrigTriglyceridestotal white blood cell countred blood cell countMean corpuscular volumeBUNDHADimethylsulfoxideOrganisation for Economic Co-operation and DevelopmentSodiumsodium azideSubchronic toxicityCyclophosphamideHemoglobin concentrationMotor activitymean corpuscular hemoglobinmedian lethal doseMean corpuscular hemoglobin concentrationAlgal oilblood urea nitrogenhematocritHgbNo observed adverse effect levelPotassiumCode of Federal Regulationsglobtotal proteinChloridetotal cholesterolCalciumGlobulinGlucFasting glucose
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Authors
D. Schmitt, N. Tran, J. Peach, M. Bauter, P. Marone,