| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5852707 | Food and Chemical Toxicology | 2012 | 18 Pages |
Abstract
⺠H1299 cells were more sensitive to phenethyl isothiocyanate than A549 cells. ⺠The inhibitory effect of PEITC was dose-dependent but not time-dependent at low concentrations of PEITC. ⺠PEITC induced disassembly of stress fibers and degradation of tubulin which, most likely, contributed to cell death induction. ⺠The apoptosis-inducing potency of PEITC is the main factor responsible for cell growth inhibition. ⺠H1299 cells exhibited morphological features of mitotic catastrophe.
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Authors
Andrzej Pawlik, Mariusz Andrzej Szczepanski, Anna Klimaszewska, Lidia Gackowska, Agnieszka Zuryn, Alina Grzanka,