| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5852712 | Food and Chemical Toxicology | 2012 | 10 Pages |
Abstract
⺠The p53+/â mouse was used to assess the toxicity and carcinogenicity of fumonisin B1. ⺠Fumonisin B1 was hepatotoxic and hepatocarcinogenic to male mice. ⺠p53 and related pathways play a secondary role in responding to fumonisin B1. ⺠Responses in p53+/â mice indicate that fumonisin B1 is a non-genotoxic carcinogen. ⺠Hepatotoxicity BMD modelling was consistent with the NOEL for rat nephrotoxicity.
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Authors
Genevieve Bondy, Rekha Mehta, Don Caldwell, Laurie Coady, Cheryl Armstrong, Marc Savard, J. David Miller, Emily Chomyshyn, Roni Bronson, Nicholas Zitomer, Ronald T. Riley,