| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5852722 | Food and Chemical Toxicology | 2012 | 11 Pages |
Abstract
⺠Oleic acid, dose dependently increased transport of mitoxantrone, a BCRP substrate, across Caco-2 cell monolayers. ⺠Oleic acid increased gene expression of BCRP in Caco-2 cells after 6 h exposure. ⺠Accumulation of mitoxantrone in Caco-2 cells increased when cells were exposed to oleic acid at 2 mM or higher. ⺠The effect of oleic acid on mitoxantrone transport was not dependent on the presence of the oleic acid emulsion.
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Authors
Bitte Aspenström-Fagerlund, Jonas Tallkvist, Nils-Gunnar Ilbäck, Anders W. Glynn,