Acute oral toxicity of 3-MCPD mono- and di-palmitic esters in Swiss mice and their cytotoxicity in NRK-52E rat kidney cells

Article ID	Journal	Published Year	Pages	File Type
5852763	Food and Chemical Toxicology	2012	7 Pages	PDF

Abstract

âº LD50 value of 3-MCPD 1-monopalmitate was 2676.81Â mg/kg body weight. âº LD50 value of 3-MCPD dipalmitate was greater than 5000Â mg/kg body weight. âº 3-MCPD 1-monopalmitate and dipalmitate caused tubular necrosis, protein casts and decrease of spermatids in Swiss mice. âº 3-MCPD 1-monopalmitate displayed cytotoxicity to NRK-52E rat kidney cells. âº 3-MCPD dipalmitate had no cytotoxicity to NRK-52E rat kidney cells.

Keywords

IC50 Lactate dehydrogenase activity 3-MCPD GHS OECD LD50 DMEM 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide 3-Chloro-1,2-propanediol 50% inhibitory concentration DMSO H&E MTT European Union standard error of mean Dimethylsulfoxide Organization for Economic Cooperation and Development Acute oral toxicity Cytotoxicity LDH Dulbecco’s modified eagle’s medium SEM median lethal dose Hematoxylin and Eosin body weight