| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5852864 | Food and Chemical Toxicology | 2012 | 7 Pages |
Abstract
⺠Beetroot juice modulates the effect of NDEA on cytochromes P450 1A1, 1A2, 2E1 and 2B. ⺠Beetroot juice increases the activity of phase II enzymes: NQO1 and GST. ⺠Beetroot juice reduces the genotoxic effect of NDEA and the level of liver injury biomarkers. ⺠Metabolic alterations induced by beetroot juice feeding may protect against liver damage.
Keywords
N-nitrosodiethylamineCDNBethoxyresorufin-O-deethylaseLMPERODCytochromes P450sorbitol dehydrogenaseNQO1ALTNAD(P)H:quinone oxidoreductase-1NDEAMRODGSTSDHNMPPNPHPRODGGTMethoxyresorufin-O-demethylaseDPIP1-chloro-2,4-dinitrobenzene2,6-dichlorophenolindophenolCYPsp-nitrophenol hydroxylaseROSBeetroot juiceASTAspartate aminotransferaseDNA damageAlanine aminotransferaseALPAlkaline phosphataseBUNCytochrome P450lactate dehydrogenaseLDHNormal melting pointlow melting pointblood urea nitrogengamma glutamyl transferaseglutathione S-transferaseReactive oxygen species
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Authors
Violetta Krajka-Kuźniak, Hanna Szaefer, Ewa Ignatowicz, Teresa Adamska, Wanda Baer-Dubowska,