| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5852912 | Food and Chemical Toxicology | 2012 | 8 Pages |
Abstract
⺠HMGB1 is pro-inflammatory cytokine as a mediator of vascular inflammation. ⺠Phlorotannins inhibited LPS induced HMGB1 release. ⺠Phlorotannins inhibited HMGB1-mediated hyperpermeability in vitro and in vivo. ⺠Rutin inhibited HMGB1-mediated inflammatory responses. ⺠Hydroxyl groups on dieckol positively regulate these vascular barrier protective effects.
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Authors
Tae Hoon Kim, Sae-Kwang Ku, Taeho Lee, Jong-Sup Bae,