| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5852968 | Food and Chemical Toxicology | 2012 | 6 Pages |
Abstract
⺠Fibroproliferative diseases are prominent causes of morbidity and mortality worldwide and may lead to metastatic cancer. ⺠Pirfenidone has been proposed as an alternative treatment in various pathologies that develop fibrosis. ⺠The erythrocyte micronucleus assay is a simple and highly informative method that detects in vivo chromosome aberrations. ⺠No evidence of genotoxic or cytotoxic effects of pirfenidone were observed in two adult rodent models. ⺠No genotoxic effects or cytotoxicity were observed in newborn rats transplacentally exposed to pirfenidone.
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Authors
Blanca E. Alcántar-DÃaz, Belinda C. Gómez-Meda, Guillermo M. Zúñiga-González, Ana L. Zamora-Perez, Jaime González-Cuevas, Bertha A. Álvarez-RodrÃguez, MarÃa Guadalupe Sánchez-Parada, Jesús J. GarcÃa-Bañuelos, Juan Armendáriz-Borunda,