Pycnogenol modulates apoptosis by suppressing oxidative stress and inflammation in high glucose-treated renal tubular cells

Article ID	Journal	Published Year	Pages	File Type
5853105	Food and Chemical Toxicology	2011	6 Pages	PDF

Abstract

âº Pycnogenol has a potent the anti-inflammatory efficacy. âº Its actions may relate to suppression of glucose-mediated apoptotic action. âº Pycnogenol may have therapeutic potentials against diabetic nephropathy.

Keywords

NF-κB DMEM/F-12 DHR 123 FCS DAPI DCFH-DA iNOS NBT TBARS COX-2 PBS FITC 2′,7′-dichlorofluorescein diacetate 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide MTT inflammation nitro blue tetrazolium Oxidative stress Apoptosis dihydrorhodamine 123 fetal calf serum inducible nitric oxide synthase Cyclooxygenase-2 Nuclear factor-kappa B Phosphate buffered saline fluorescein isothiocyanate thiobarbituric acid reactive substances Diabetic nephropathy Pycnogenol Reactive species