| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5853148 | Food and Chemical Toxicology | 2011 | 7 Pages |
Abstract
⺠Rats were exposed perinatally to methylmercury administered either alone or with a Rhododendron tomentosum extract. ⺠Co-exposure effects on pups growth and development, oxidative stress, glutamatergic system and neurobehaviour were assessed. ⺠Effects of co-exposure on molecular endpoint were very dependant on the developmental stage and endpoint assessed. ⺠However, modulation of molecular endpoints did not lead to significant alterations of MeHg's effects on rat neurobehaviour.
Keywords
MeHgpentoxyresorufin-O-dealkylasePRODNMDA-Rethoxyresorufin-O-deethylaseERODTBARSPPIGSHPNDTHgBRODneurodevelopmentBehaviourgestational daypostnatal dayPhytochemicalsMethylmercuryPrepulse inhibitionthiobarbituric acid reactive substancesRatbody weightreduced glutathioneTotal mercuryN-methyl-d-aspartate receptor
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Authors
Paleah Black, Lijie Niu, Manisha Sachdeva, David Lean, Raymond Poon, Wayne J. Bowers, Hing Man Chan, John T. Arnason, Guillaume Pelletier,