| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5853214 | Food and Chemical Toxicology | 2011 | 8 Pages |
Abstract
⺠Nephrotoxicity is the dose limiting side effects of cisplatin, an anticancer agent. ⺠Carnosic acid significantly attenuated the renal injury, oxidative stress and apoptosis associated with cisplatin therapy. ⺠Both biochemical and histopathology data correlate the renoprotective effect of carnosic acid. ⺠Carnosic acid may find role in reducing the complications of renal dysfunction with cisplatin in cancer chemotherapy.
Keywords
GSSHi.p.DCFH-DADTNBMDANEDCATNADPHGSHGST2,7-dichlorofluorescein diacetateAc-DEVD-AMCGSH-PxPeriodic Acid Schiffcarnosic acidApoptosisBUNintra peritonealFree radicalsSODSuperoxide dismutasecisplatinmalondialdehydeNephrotoxicityPASblood urea nitrogenNitric oxidebody weightCatalasereduced glutathioneglutathione S-transferaseglutathione oxidizedglutathione reductaseglutathione peroxidase
Related Topics
Life Sciences
Agricultural and Biological Sciences
Food Science
Authors
Bidya Dhar Sahu, Kiran Kumar Reddy Rentam, Uday Kumar Putcha, Madhusudana Kuncha, Ganga Modi Naidu Vegi, Ramakrishna Sistla,