| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5853354 | Food and Chemical Toxicology | 2012 | 6 Pages |
Abstract
⺠2-Pentylpiperidine, named conmaculatin, was identified from the essential oil of Conium maculatum L. ⺠The new alkaloid was synthesized in 8 steps from cyclohexanol and in 12% total yield. ⺠The biosynthesis of the alkaloid should follow the acetate pathway, known for coniine. ⺠Conmaculatin was found to be lethal to mice in doses higher than 20 mg/kg. ⺠2-Pentylpiperidine showed a strong antinociceptive effect in a dose dependent manner.
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Authors
Niko RaduloviÄ, Nevenka ÄorÄeviÄ, Marija DeniÄ, Mariana Martins Gomes Pinheiro, Patricia Dias Fernandes, Fabio Boylan,