| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5853504 | Food and Chemical Toxicology | 2012 | 10 Pages |
Abstract
⺠High bioavailability of parabens after oral and subcutaneous administrations in rats. ⺠Partial bioavailability of parabens after topical administration in rats. ⺠The sole systemic exposure agent after administration of parabens was PHBA. ⺠Parabens, as preservatives in PCP, mainly produces human systemic exposure to PHBA. ⺠The parabens in PCP offer significant benefits and pose no risk to human health.
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![Systemic exposure to parabens: Pharmacokinetics, tissue distribution, excretion balance and plasma metabolites of [14C]-methyl-, propyl- and butylparaben in rats after oral, topical or subcutaneous administration](/preview/png/5853504.png "First Page Preview: Systemic exposure to parabens: Pharmacokinetics, tissue distribution, excretion balance and plasma metabolites of [14C]-methyl-, propyl- and butylparaben in rats after oral, topical or subcutaneous administration")
Authors
Nicolas Aubert, Thibault Ameller, Jean-Jacques Legrand,