Article ID Journal Published Year Pages File Type
5853643 Food and Chemical Toxicology 2012 7 Pages PDF
Abstract
► Xanthohumol (XN) is not a bacterial mutagen and does not induce genomic instability. ► XN prevents PhIP and MeIQx induced DNA damage at nanomolar concentrations. ► The mechanism of protection involves up-regulation of UGT1A1 gene expression. ► XN may exert chemoprevention at doses relevant for human dietary exposure.
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Related Topics
Life Sciences Agricultural and Biological Sciences Food Science
Preview
Protective effects of xanthohumol against the genotoxicity of heterocyclic aromatic amines MeIQx and PhIP in bacteria and in human hepatoma (HepG2) cells
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