| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5853664 | Food and Chemical Toxicology | 2012 | 9 Pages |
Abstract
⺠Aurentiacin, a naturally occurring chalcone, has a potent anti-inflammatory effect in vitro and in vivo. ⺠Aurentiacin reduces the level of pro-inflammatory mediators and cytokines. ⺠Aurentiacin inhibits NF-κB activation through blocking nuclear translocation of p65. ⺠Aurentiacin also controls MAPK and HAT, that is concerned with NF-κB signaling.
Keywords
ERKI-κB kinaseI-κBIKKiNOSNF-κBJnkLPSIL-6c-Jun N-terminal kinaseMAPKElectrophoretic mobility shift assaychromatin immunoprecipitationinterleukin-6tumor necrosis factor-αinducible nitric oxide synthaseEMSA یا electrophoretic mobility shift assay TNF-αnuclear factor-κBlipopolysaccharideinhibitor of κBNitric oxideCHiPextracellular signal-regulated kinase
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Authors
Young-Joo Kim, Han-Cheon Kim, Hyeonseok Ko, Evangeline C. Amor, Jong Wha Lee, Hyun Ok Yang,