| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5853668 | Food and Chemical Toxicology | 2012 | 9 Pages |
Abstract
⺠We found that Schizandrin significantly blocked high glucose induced mesangial cell proliferation. ⺠That compound also inhibits extracellular matrix protein accumulation in mesangial cells under hyperglycemic conditions. ⺠The effect of Sch is mediated from preventing of NADPH oxidase-stimulated signaling by high glucose.
Keywords
ECMMTSMMCsNADPHDcfDPIDMEMPBSPI3K2′,7′-dichlorofluoresceinERK1/2MAPKROSSchizandrinNADPH oxidasediphenylene iodoniumphosphoinositide 3-kinaseExtracellular matrixPhosphate-buffered salineDulbecco’s modified eagle’s mediummitogen activated kinaseDiabetic nephropathynicotinamide adenine dinucleotide phosphateextracellular signal-regulated kinase 1/2high glucoseReactive oxygen species
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Authors
Seung-Il Jeong, Sang-Jun Kim, Tae-Ho Kwon, Kang-Yeol Yu, Seon-Young Kim,