| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5853681 | Food and Chemical Toxicology | 2012 | 9 Pages |
Abstract
⺠Gingerdione, an active component from ginger, and its derivative I6 have been demonstrated to inhibit HL-60 cell growth. ⺠Neuronal death induced by I6 displayed apoptotic characteristics. ⺠I6-induced reduction of mitochondrial viability and neuronal apoptosis were inhibited by vitamin E. ⺠I6 induces neuronal death by promoting intracellular ROS production. ⺠The ROS results in cytochrome c release and activation of mitochondria-mediated intrinsic death pathway.
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Authors
Chia-Ho Lin, Po-See Chen, Sheng-Chu Kuo, Li-Jiau Huang, Po-Wu Gean, Ted-H Chiu,