| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5853695 | Food and Chemical Toxicology | 2012 | 10 Pages |
Abstract
⺠First report on the cytotoxicity of aloe-emodin (AE) in HK-2 cells. ⺠AE can induce apoptosis through G2/M phase arrest and caspase-3 activation. ⺠Endoplasmic reticulum stress is involved in AE-induced apoptosis. ⺠AE should be considered as a potential nephrotoxicant.
Keywords
eIF2αtribbles-related protein 3CHAC1protein kinase-like ER kinaseHK-2GADD153DR5TRAF2ASK1GRP78TRITCThapsigarginXBP1IRE1UPRTRB3FITCATFMTTp-JnkAloe-emodinEndoplasmic reticulum stressTemCHOPApoptosisHK-2 cellsendoplasmic reticulumeukaryotic initiation factor 2 alphatumor necrosis factor receptor-associated factor 2Phosphatidylserineactivating transcription factorfluorescein isothiocyanatetraTransmission electron microscopeUnfolded protein responseX-box binding protein 1glucose-regulated protein 78Propidium iodidePERKapoptosis signal-regulating kinase 1death receptor 5
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Authors
Shaohua Zhu, Jing Jin, Yan Wang, Zizhang Ouyang, Chen Xi, Jia Li, Yuwen Qiu, Jinzhi Wan, Min Huang, Zhiying Huang,