| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5853721 | Food and Chemical Toxicology | 2011 | 7 Pages |
Abstract
⺠The mutagenicity of 3,6-di-substituted acridines was evaluated by the Ames test (TA97a). ⺠Their clastogenicity was assessed by the micronucleus assay as compared to their cytotoxicity. ⺠Simple symmetric molecules were more genotoxic than asymmetric structures. ⺠Cytotoxicity was decoupled from genotoxicity by introducing asymmetric and bulky chemical groups. ⺠3-acetamido-6-(4-fluorobenzamido)acridine was the most promising anticancer compound.
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Authors
Carole Di Giorgio, Yohann Benchabane, Gérard Boyer, Philippe Piccerelle, Michel De Méo,