| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5853738 | Food and Chemical Toxicology | 2011 | 7 Pages |
Abstract
⺠This study investigated the long-term (12 months) oral toxicity of D-004 in rats. ⺠The histological lesions found in treated animals are commonly present in this specie. ⺠No evidences of D-004-related toxicity were detected. ⺠The highest dose tested was a no-observed adverse effect level in this study.
Keywords
ADRRBCsDHTNOAELPHEWBCsALTAdrenoreceptorsRed blood cellsASTAspartate aminotransferaseAlanine aminotransferaseAChEAdverse effectsAcetylcholinesteraseFatty acidsanalysis of varianceANOVAtestosteroneDihydrotestosteroneChronic toxicityLower urinary tract symptomsphenylephrineLUTSBenign prostatic hyperplasiaBPHno-observed-adverse-effect levelwhite blood cells
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Food Science
Authors
A. Gutiérrez, R. Gámez, M. Noa, R. Mas, D. Arencibia, B. Pardo, M. Valle, A. Oyarzábal, D. Curveco, H. GarcÃa, E. Goicochea, N. Mendoza, S. Jiménez.,