| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5853744 | Food and Chemical Toxicology | 2011 | 7 Pages |
Abstract
⺠Genotoxicity of combined treatments of ochratoxin A (OTA) and aflatoxin B1 (AFB1) in Hep G2 cells. ⺠DNA damage evaluated by the comet assay using restriction enzymes FPG and endo III. ⺠3 h + S9 mix and 24 h treatments of AFB1 increased DNA strand breaks and AP sites; FPG detected additional strand breaks. ⺠OTA gave negative results but produced a significant decrease of AFB1 genotoxicity. ⺠A possible explanation may be that AFB1 and OTA compete for the same CYP enzymes representing a bioactivation route for AFB1.
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Authors
L.A. Corcuera, L. Arbillaga, A. Vettorazzi, A. Azqueta, A. López de Cerain,