| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5853753 | Food and Chemical Toxicology | 2011 | 13 Pages |
Abstract
⺠This paper describes the application of an MOE approach to tobacco smoke toxicants. ⺠MOEs were generally consistent for each smoke toxicant using diverse data sets. ⺠Segregation into priorities is discussed using 13 worked examples of MOEs. ⺠This approach facilitates prioritisation for more complex risk assessments.
Keywords
BMDSNOAELLOAELNNKMOAIPCsPBPKBMREFSABMDNNNCASAkaike’s information criteriaAICILSINTPN-nitrosonornicotinePOD4-(methylnitrosamino)-1-(3-pyridyl)-1-butanoneB(a)PALARAIARC یا International Agency for Research on CancerInternational Agency for Research on CancerUnited States Environmental Protection AgencyEuropean Food Safety AuthorityRisk assessmentISONational Toxicology ProgramBenzo(a)pyrenecardiovascular diseaseChronic obstructive pulmonary diseaseCOPDMargin of exposureMode of actionchemical abstract servicebenchmark doseCVDWorld Health OrganizationInternational Organization for StandardizationTobacco smokePhysiologically based pharmacokineticBenchmark dose lower confidence limitModellingbenchmark responseAs Low As Reasonably AchievableInternational Life Sciences InstitutePoint of departureNo observed adverse effect levelMOEUnited KingdomLowest observed adverse effect levelWHOUSEPA
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Authors
F.H. Cunningham, S. Fiebelkorn, M. Johnson, C. Meredith,