| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5853934 | Food and Chemical Toxicology | 2011 | 7 Pages |
Abstract
⺠Di(2-ethylhexyl)phthalate (DEHP) is the most abundantly used plasticizer. ⺠DEHP has deleterious effect potential on male reproductive system. ⺠Its main metabolite MEHP induced p53 and p21 in LNCaP cells. ⺠Overall data showed that oxidative stress underlies toxicities of DEHP and MEHP. ⺠Selenium was protective against the oxidative potential of DEHP and MEHP.
Keywords
P21PPARαDEHPPPARγFCSGPXNACDcfTrxRp53DR5FBSMEHPPBSDAB2′,7′-dichlorofluorescein3,3′-diaminobenzidineN-acetylcysteineperoxisome proliferatorROSDi(2-ethylhexyl)phthalatefetal bovine serumfetal calf serumSelenomethioninesodium seleniteSeleniumPhosphate buffered salineMono(2-ethylhexyl)phthalateglutathione peroxidaseReactive oxygen speciesdeath receptor 5peroxisome proliferator-activated receptor γperoxisome proliferator-activated receptor α
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Authors
P. ErkekoÄlu, W. Rachidi, O.G. Yüzügüllü, B. Giray, M. Ãztürk, A. Favier, F. Hıncal,