Resveratrol preserves cardiac function, but does not prevent endothelial dysfunction or pulmonary inflammation after environmental tobacco smoke exposure

Article ID	Journal	Published Year	Pages	File Type
5853937	Food and Chemical Toxicology	2011	8 Pages	PDF

Abstract

âº Environmental tobacco smoke (ETS) impaired endothelial function and increased oxidative stress. âº ETS also caused lung and systemic inflammation that was not reversed by resveratrol. âº Resveratrol did help preserve cardiac function in pigs exposed to ETS. âº The French paradox may be due to resveratrol protection from cardiovascular effects of smoking.

Keywords

Carboxyhemoglobin CYP1A1 AHR BAL EDV FMD ETs ESV PAH met-Hb met-hemoglobin CO-Hb Oxy-Hb NOx Endothelial dysfunction Pulmonary inflammation Flow-mediated dilation Chronic obstructive pulmonary disease COPD Oxidative stress End-diastolic volume end-systolic volume environmental tobacco smoke Resveratrol cytochrome P450 1A1 bronchoalveolar lavage carbon monoxide Nitrate/nitrite Nitric oxide Polycyclic aromatic hydrocarbon CRP ejection fraction aryl hydrocarbon receptor