| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5853948 | Food and Chemical Toxicology | 2011 | 7 Pages |
Abstract
⺠Apigenin induced apoptosis via caspase cascade in human hepatocellular carcinoma, huh-7 cells. ⺠The mechanism of apigenin-induced apoptosis was including down-regulation of vimentin and related with a decrease of type I collagen, VEGF, and MMP-8. ⺠Vimentin plays a crucial role in angiogenesis and cell migration. ⺠Vimentin might potentially be a key factor in the mechanism of APG-induced apoptosis in HCC, huh-7 cells, via anti-angiogenesis.
Keywords
PRDX2APGVIMTdTVimentinCDART-CES2-DEIC50Prdx1MmpsHCCAngiogenesisApigeninTwo-dimensional electrophoresisterminal deoxynucleotidyl transferaseEnzyme-linked immunosorbent assayELISAApoptosisintermediate filamentcytidine deaminaseVascular Endothelial Growth Factor (VEGF)MALDI-TOF/MSMatrix metalloproteinasesdutMigrationhalf-maximal inhibitory concentrationPeroxiredoxin-1peroxiredoxin-2Hepatocellular carcinoma
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Authors
Bo Ra Kim, Young Keul Jeon, Myeong Jin Nam,