Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5853970 | Food and Chemical Toxicology | 2010 | 8 Pages |
Abstract
Rev7⢠is an indigestible gum polymer used for the manufacturing of chewing gum. It allows for the formulation of chewing gum with low adhesion; thus can be readily removed from surfaces such as sidewalks, clothing, carpets and furniture. In a toxicological safety assessment, Rev7⢠was found to be non-mutagenic in the AMES assay. The highest concentration tested in a mouse lymphoma thymidine kinase locus gene mutation assay induced a slight but biologically relevant increase in mutations under non-metabolic activation conditions after 24 h. Because of this finding, a mouse micronucleus assay was performed, and the test article was found to be negative for inducing chromosomal damage. A 28-day repeated oral toxicity study resulted in a NOAEL of 80,000 ppm; the highest concentration tested. Rev7⢠was found to be free from contaminants such as heavy metals, monomers, and solvents. Lastly, Rev7⢠did not demonstrate skin-sensitizing properties in the murine local lymph node assay.
Keywords
cis-PolyisopreneNOAELMTDBHTEECOECDGPCmPEGGRASDMSOGC/MSADIEuropean UnionEuropean Economic Communityethylene oxidegenerally recognized as safeEuropean CommunityMaximum tolerated doseAcceptable daily intakeDimethyl sulfoxideOrganization for Economic Co-operation and Developmentgas chromatography–mass spectrometryICP-MSEuropean PharmacopeiaMethoxypolyethylene glycolbutylated hydroxytolueneNo observed adverse effect levelpolyethylene glycolPEGPiPHigh pressure liquid chromatographyHPLCGel permeation chromatographyGas chromatography with flame ionization detectorGas chromatography
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Authors
T.M. Farber, A.E. Clewell, J.R. Endres, J. Hauswirth, M. Van Gemert, A.G. Schauss, C.A. Sheane,