Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5853998 | Food and Chemical Toxicology | 2010 | 7 Pages |
Abstract
We isolated anthocyanins from fruits of Vitis coignetiae Pulliat, characterized the anthocyanin profile, and investigated the anti-invasive effects of the anthocyanins on human colon cancer cells. The anthocyanins inhibited cell invasion in a dose-dependent manner, as measured by Matrigel invasion assays, by suppression of matrix metalloproteinase (MMP)-2 and MMP-9 expression. The anti-invasive activity of the anthocyanins was associated with modulation of constitutive nuclear factor κB (NF-κB) activation. The activation of NF-κB triggered by tumor necrosis factor-α was also inhibited by the anthocyanins through suppression IκBα phosphorylation. AIMs inhibited the expression of NF-κB-regulated proteins. In conclusion, this study suggested that the anthocyanins isolated from fruits of V. coignetiae Pulliat should have anti-invasive activities on human colon cancer cells and the activities should be related to the inhibition of NF-κB-regulated proteins such as MMP-2 and MMP-9 expression through the inhibition of NF-κB activation.
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Authors
Jeong Won Yun, Won Sup Lee, Min Jeong Kim, Jing Nan Lu, Myung Hee Kang, Hoon Gu Kim, Dong Chul Kim, Eun Ju Choi, Jin Young Choi, Hae Gyeong Kim, Yun-Kyoung Lee, Chung Ho Ryu, GonSup Kim, Yung Hyun Choi, Ock Jin Park, Sung Chul Shin,