Inhibitory effects of (−)-α-bisabolol on LPS-induced inflammatory response in RAW264.7 macrophages

► Anti-inflammatory effect of (−)-α-bisabolol in RAW264.7 cells. ► (−)-α-Bisabolol inhibits LPS-induced expression of iNOS and COX-2 genes. ► (−)-α-Bisabolol reduces LPS-induced phosphorylation of IκBα. ► LPS-induced phosphorylation of ERK and p38 is attenuated by (−)-α-bisabolol. ► (−)-α-Bisabolol inhibits NF-κB and AP-1 (ERK and p38) signaling.